A public service of the

Silver Safety Council
Doctors, university professors, and world leaders in health-freedom advocacy

Guidelines for the safe use of silver supplements in human health

Home of the
Silver Safety Pyramid

About Us
Silver Safety Council

Does the safety calculations for you
Using the Calculations
Converting drops to sprays, and more
Adobe PDF
Guideline, Calculation
and Pyramid together
US Government
Silver safety sites
Education & FAQ
Ionic and colloidal,
PPM, particle size, and much more
Calculating Cost
Calculate and compare the cost fo any two silver products per mg of silver

Contact us


Last updated:
January 2, 2022

© 1995-2022
Invision International
Health Solutions, Inc.
All rights reserved.


US Government Sites on Silver Safety

Environmental Protection Agency - Reference Dose (RfD) for Silver

The Environmental Protection Agency's Integrated Risk Information System (I.R.I.S.) on Silver provides what is called the Reference Dose (RfD) for recommended limits on daily oral intake of silver. It is the most definitive and concise US government guideline on safe intakes levels for silver. It is at the following link:

The Reference Dose (RfD) that it describes is the guideline that all other EPA agencies, including those that set the drinking water standards, refer to as the most authoritative guideline.

In reading the document, note that the RfD that is represented as 5E-3 mg/kg/day should be read as follows: 5 to the exponent of minus 3 (0.001) = 0.005 milligrams per kilogram of body weight per day.

What this means is: 5mcg of silver per kg of body weight per day. In other words, 5mcg/kg/day.

The EPA's I.R.I.S. on Silver states:

"The critical effect in humans ingesting silver is argyria, a medically benign but permanent bluish-gray discoloration of the skin. Argyria results from the deposition of silver in the dermis and also from silver-induced production of melanin. Although silver has been shown to be uniformly deposited in exposed and unexposed areas, the increased pigmentation becomes more pronounced in areas exposed to sunlight due to photoactivated reduction of the metal. Although the deposition of silver is permanent, it is not associated with any adverse health effects. No pathologic changes or inflammatory reactions have been shown to result from silver deposition."

"Argyria, the critical effect upon which the RfD for silver is based, occurs at levels of exposure much lower than those levels associated with other effects of silver."

CDC - Agency for Toxic Substances and Disease Registry - Silver

The CDC's Agency for Toxic Substances and Disease Registry (ATSDR) on Silver is the US government's most extensive compilation of data on silver safety and toxicity. It is at the following link:

The ATSDR on Silver states:

"Most people are exposed daily to very low levels of silver mainly in food and drinking water, and less in air. The silver in these sources is at least partially due to naturally occurring silver in water and soil."

"Drinking water supplies in the United States have been found to contain silver levels of up to 80 ppb. Surveys show that one-tenth to one third of samples taken from drinking water supplies (both groundwater and surface water) contain silver at levels greater than 30 ppb."

"Most of the silver that is eaten or breathed in leaves the body in the feces within about a week."

"Since at least the early part of this century, doctors have known that silver compounds can cause some areas of the skin and other body tissues to turn gray or blue-gray. Doctors call this condition "argyria." Argyria occurs in people who eat or breathe in silver compounds over a long period (several months to many years). A single exposure to a silver compound may also cause silver to be deposited in the skin and in other parts of the body; however, this is not known to be harmful. It is likely that many exposures to silver are necessary to develop argyria. Once you have argyria, it is permanent. However, the condition is thought to be only a "cosmetic" problem. Most doctors and scientists believe that the discoloration of the skin seen in argyria is the most serious health effect of silver."

"Silver does have helpful uses. For example, silver nitrate was used for many years as drops in newborns' eyes to prevent blindness caused by gonorrhea, and it is also used in salves for burn victims. Some water treatment methods (including water filters) also use a form of silver to kill bacteria."



The Silver Safety Calculation upon which the guidelines on this site are based was developed by the creator of Silver 100™ Ionic Silver Complex with Opti-Silver™.
Silver 100™ was designed for optimally efficient delivery of silver ions into the human body.
The suggested usage on the label for Silver 100™ fully complies with the Silver Safety Guideline.
You can learn much more about Silver 100™ with Opti-Silver™ at:
"To a chemist,
Opti-Silver represents
a brilliant chemical formulation..."

— Don Baird, PhD, chemistry professor, Nova Southeastern University; former director of the Department of Chemistry, Florida Atlantic University


* The EPA did not create and has not endorsed the Silver Safety Guideline or the Silver Safety Calculation. It has not represented that limiting
silver intake from silver supplements to 25% of the RfD will limit total silver intake to safe levels or adheres to the RfD guideline.